Coronavirus:

[chuck]

I spent most of my career working with antibodies and the development of antibody drugs...... It's usually a very slow methodical process. Taking something from the lab to the clinic trial stage generally takes years. Last clinical trial out of my lab to a lot of years......

Getting around clinical or taking short cuts in clinical is is a really bad idea.

Speeding up/weeding out stuff to get to clinical is where you have the ability to save time. Even something like IBM's Watson can help correlate disparate data sets and lead to potential new insights/paths. The number and type of in vitro tests can be streamlined and possibly an earlier and more focused in-vivo. If there is money available those could be run in parallel or near parallel.

Stuff that looked good in vitro or even in vivo often falls apart in clinical because the side effects are so unpredictable. I find it amusing that a fair number of drugs being marketed today were never intended for treating the maladies they are treating. They were originally intended for something completely different. The clinical's uncovered side effects that were able to "fix" something. Silver lining!

[Rufus T. Firefly]

Stuff that looked good in vitro or even in vivo often falls apart in clinical because the side effects are so unpredictable.

Okay, in vitro is not predictive of in vivo -- start there. Animal models work to a point but few are fully predictive. None of that has anything to do with side effects -- entirely on the side of efficacy and PK/PD being radically different. There are also species differences.

I find it amusing that a fair number of drugs being marketed today were never intended for treating the maladies they are treating. They were originally intended for something completely different. The clinical's uncovered side effects that were able to "fix" something. Silver lining!

Many have come back for use since they were never looked at or could not be looked at for other diseases - today's screening sophistication makes a lot of re-discovery and re-purposing possible like Thalidomide.

[Chris Webster]

https://www.dailytarheel.com/article/20 ... -edit-0816

[Rufus T. Firefly]

Lovely...

[MurphOnMillerAve]

After watching the News recently. , I'm going to conclude this is not the time for me to drive from NJ , thru PA , and into NY, with the Upstate area around Cortland as my goal.

I say that because it seems I should expect to get stopped by state troopers, at least somewhere along the way, and challenged, even required to restrict myself at some point along the way, even being stopped from returning to NJ at places like the tollbooths at Delaware Water Gap, along Rt80.

Right ?

I know I've asked this question here previously, butt ( ) matters have changed and evolved so I am even further concerned.

What say yee, dudes?

[rogruth]

Murph,
You better find some places in New Jersey to visit for a while.
Aren't there some woods/forests that you can visit in the state?

[Rufus T. Firefly]

After watching the News recently. , I'm going to conclude this is not the time for me to drive from NJ , thru PA , and into NY, with the Upstate area around Cortland as my goal.

I say that because it seems I should expect to get stopped by state troopers, at least somewhere along the way, and challenged, even required to restrict myself at some point along the way, even being stopped from returning to NJ at places like the tollbooths at Delaware Water Gap, along Rt80.

I have very serious doubts about state troopers stopping anyone just because of out of state tags --- I've been driving back & forth to my place in PA across MD w/o any issues at all. You might note that people are commuting to work across state lines all the time. I see tags from NY,NJ, PA, MD, VA, WVa and OH when I'm out and the police are not stopping them for being out of state.

Toll booths in PA are not manned - all electronic - signs are up for that and "We'll bill you..." signs are up, too.

OTOH, NY is not a state I drive into so if there's any unknown weirdness, it's there............ok, NJ is........

[MurphOnMillerAve]

That's very helpful .
I thank you, both, for having the interest enough in my shenanigans to reply .

You've given me more to think about. I think its best I just stay around here.

My wanderlust can wait. Until?
There's the question, too.

[chuck]

If your concern is going through PA, don't. Just go north on 287 till you pick up 17 in New York and then switch over to 81 in Binghamton to go north to Cortland.

[robert.]

After watching the News recently. , I'm going to conclude this is not the time for me to drive from NJ , thru PA , and into NY, with the Upstate area around Cortland as my goal.

I say that because it seems I should expect to get stopped by state troopers, at least somewhere along the way, and challenged, even required to restrict myself at some point along the way, even being stopped from returning to NJ at places like the tollbooths at Delaware Water Gap, along Rt80.

I have very serious doubts about state troopers stopping anyone just because of out of state tags --- I've been driving back & forth to my place in PA across MD w/o any issues at all. You might note that people are commuting to work across state lines all the time. I see tags from NY,NJ, PA, MD, VA, WVa and OH when I'm out and the police are not stopping them for being out of state.

Toll booths in PA are not manned - all electronic - signs are up for that and "We'll bill you..." signs are up, too.

OTOH, NY is not a state I drive into so if there's any unknown weirdness, it's there............ok, NJ is........

NYC has safety check outside of the tunnels(inbound). Random stops conducted by the sheriff. A small legal battle is brewing to stop it. 14 day self quarantine only applies to vacationers. People traveling for work do not need to quarantine.

[Rufus T. Firefly]

NYC has safety check outside of the tunnels(inbound). Random stops conducted by the sheriff. A small legal battle is brewing to stop it. 14 day self quarantine only applies to vacationers. People traveling for work do not need to quarantine.

Easy fix to that is to set up random stops on those departing outbound - we don't want NYC exporting.......

Anyway, NYC is one place I'd be making a big circle around regardless.

[robert.]

Ironic how Cuomo was upset. RI. Was stopping New Yorkers. Now NYC’s sheriff is stopping out of state travelers. ( nobody is being denied entry to nyc) just questioning.

[Rufus T. Firefly]

Ironic how Cuomo was upset. RI. Was stopping New Yorkers. Now NYC’s sheriff is stopping out of state travelers. ( nobody is being denied entry to nyc) just questioning.

Hilarious.

[HONDO74]

A Yale administrator told students to prepare for 'possibly deaths' — and it shows what a predictable disaster reopening is
https://news.yahoo.com/yale-administrat ... 55962.html

On Tuesday, the Yale Daily News, a student newspaper at the university, reported that an administrator had emailed students that their dorm experiences would be different this fall.

"We all should be emotionally prepared for widespread infections — and possibly deaths — in our communities," Laurie Santos, the head of a Yale residential college, wrote in a July 1 email to students.

The email also said students "should emotionally prepare for the fact that your residential college life will look more like a hospital unit than a residential college."

Yale plans to welcome some students back to its New Haven, Connecticut campus at the end of August and to administer coronavirus tests to students multiple times per week, but it still may not be enough to quell an outbreak similar to those at UNC or Notre Dame.

[robert.]

Notre Dame has an outbreak.
https://www.cbsnews.com/news/notre-dame ... n-classes/

Maine is requiring restaurant workers to wear their plastic face shields upside down ( you may use other face coverings). This will direct breath up and out. Instead of down and out. Your shield needs to be mounted around your neck. Not above your ears.