Coronavirus:

[Rufus T. Firefly]

..........isn’t following the classic approach of using a weakened version of the disease pathogen.

Seems that almost all of the vaccines that are in or going into trials are not following the classic approach.

6 monkeys.....that data will get this vaccine into a phase 1. Still 18 months away from approval unless it gets short cut for being exceptionally effective.

[chuck]

That has enabled the institute to skip ahead and schedule tests of its new Covid-19 vaccine on more than 6,000 people by the end of May, hoping to show not only that it is safe, but also that it works.

This is a UK study and has different rules/guidelines. They are trying to leverage what they did with the previous vaccine.

[bob turner]

I know almost nothing about vaccines, but the death trend is getting sort of under control. It started out at ten percent a day for US deaths, and the percentage has been dropping for a week. Now the absolute number of daily deaths is dropping.

When the total was 22,000 total deaths, the daily toll was around 2500. Total deaths doubled in eight days flat. Then the daily deaths flattened out to 2500, no matter the total cases. That was right around April 25. Now we are down to total daily deaths below 1500 - still a huge number, but obviously no longer exponential. We did just pass 56,000 dead, in less than six weeks. This was no joke.

We will go through 60,000 - soon -but if this trend continues, there is real hope that the first wave, at least, is coming to a less than catastrophic end.

That is all rather uneducated opinion, based on CDC and Johns Hopkins reports of daily and total deaths.

[E7]

If you can trust the accuracy of their figures. As my old Daddy who lived to be 93 said: "Don't believe anything you hear and about half what you see and you'll do OK!"

[E7]

A 50yr old female cousin of my wife's died from a Deer Tick bite's Lime Disease several years ago. That is enough for me.

LYME disease, as in Lyme, CT. If you stop eating Limes, you'll die of Scurvy!

[MurphOnMillerAve]

Thanks, E7, I fixed it.
daMurph

[Rufus T. Firefly]

[................you'll die of Scurvy!

Yes, you have to be careful about things.

[Rufus T. Firefly]

[HONDO74]

Still 18 months away from approval unless it gets short cut for being exceptionally effective.

Will this still be around in 18 months Probably be forgotten about by then unless there is a 2nd & 3rd wave of it.

If it takes a billion dollars to develop and get it approved like it does other new drugs it may get shortcut

I can't find that they had anything approved for the SARS and MERS. And from what I just read the EBOLA vaccine actually took 2 decades from when someone first started working on it.

Social distancing and wearing a mask will be the on;y thing that works for 18 months......

[Rufus T. Firefly]

Still 18 months away from approval unless it gets short cut for being exceptionally effective.

Will this still be around in 18 months Probably be forgotten about by then unless there is a 2nd & 3rd wave of it.

We are not through the "1st wave" yet.

If it takes a billion dollars to develop and get it approved like it does other new drugs it may get shortcut

No idea.

I can't find that they had anything approved for the SARS and MERS. And from what I just read the EBOLA vaccine actually took 2 decades from when someone first started working on it.

Don't recall anything approved for SARS and MERS, but then again neither was on the scale or range of this virus. Depends on when you want to declare the starting point. Last flare of Ebola that initiated the approved vaccine would put the development to approval at ~6-7 years. Again, was not a high priority item and not a big demand.

Social distancing and wearing a mask will be the on;y thing that works for 18 months......

A healthy dose of intelligence and a serious decrease in stupidity might be good to factor into the mix.

[HONDO74]

Is America’s high obesity levels leading to more coronavirus deaths?
https://www.foxnews.com/health/is-ameri ... rus-deaths

Just as the U.S. is leading the world in coronavirus deaths, it has, for decades, led the world in obesity levels too – and medical professionals are now indicating that the uncomfortable statistic is no mere coincidence.

The Centers for Disease Control and Prevention (CDC) has pinpointed “severe obesity” – those with a Body Mass Index (BMI) of 40 or more -- as being one of the groups most “at risk for complications” when it comes to coronavirus, officially referred to as COVID-19.

Adding my 2 cents to this... Remembering back to my younger years. When we went to a restaurant or ever Mk Ds what we had that was considered a meal in now just a snack.. A 5 to 10 cent coke (6 oz) was a treat. Where I last worked I would see the mostly younger generation come in with what they called a big gulp. 64 ozs of water sugar and caffeine. That was their substitute for coffee.

We now have all these all you can eat places. Seeing some of the people fill up 3 and four plates I think they feel an obligation to eat all they can. I gave up on those years ago. They kept raising the prices where I was doing the same thing to get my moneys worth.

I'm not immune to this either. On my last blood test for the first time in my history my blood sugar was elevated. And I am not a sweet eater. She said I'm on the low side of pre-diabetic so she gave me this list of what to eat and what not to. I love all the veggies on the list. The only item that I have a hard time with is no potatoes. I am not a bread eater so that one is not a problem.

[Rufus T. Firefly]

Obesity is linked to all sorts of negatives and it's been a problem for this country for decades. Many of those same negatives seem to be associated with negative or susceptibilities associated with the virus.

[Neil]

One sound hypothesis is that COVID-19 severe disease is an inflammatory disease initiated by the virus but then running out of control even after the virus is under control or gone. Obesity, particularly what is termed morbid obesity is a highly inflammatory state. Fat tissue is not inert, as previously thought, but secretes a fair number of inflammatory molecules. Our ICU docs stated that almost all of our local ICU patients are seriously obese. May explain the over representation of African-American individuals because obesity is unfortunately more common in that community. Doubt this played a role in China or Italy, as obesity is less common, but smoking and air pollution are more common.

Fools in our Federal Government are busy relaxing air pollution regs when they should be making them stricter. Both for lung disease in general and COVID-19. And now that air pollution is at an all time low, the number of patients with heart attacks and strokes at many hospitals is considerably decreased. Probably cause and effect. You'll hear more about this as data accumulate. Obesity + air pollution + smoking/vaping. Undoubtedly predisposes to death from COVID-19.

[HONDO74]

Fools in our Federal Government are busy relaxing air pollution regs when they should be making them stricter. Both for lung disease in general and COVID-19. And now that air pollution is at an all time low,

As far back as I can remember living in California who led the nation in regulations. they still have massive air pollution because they still have millions of internal combustion vehicles on their 6 lane (both ways) expressways. Regulations are not going to fix the problem. The only way is the elimination of the internal combustion vehicles.

You up the gas mileage regulations and it get accomplished and the people drive 3 times the miles they used to creating the same amount of pollution. They have many picture on the internet presently show the air clearing in the major cities of the world because people are not driving their vehicles.

So what are your idiot politicians in NYC doing besides kicking the can down the road and pointing their fingers at someone else.

[Roy]

Why the three main types of coronavirus tests can't be easily mass produced:

https://www.cnn.com/2020/04/28/us/coronavirus-testing-pcr-antigen-antibody/index.html